Russell-Myers was one of 15 siblings. Her elder brother, Robert, is better known as Brigadier Jerry, and by her mid-teens, she would occasionally perform on the Jahlove Music sound system that he worked with, and worked for three years on the Stereophonic sound system with General Echo. In 1980, producer Winston Riley was the first to take her into the studio, resulting in her first single, “Papa Dean” for his Techniques label. Russell-Myers went on to perform at Reggae Sunsplash, making her the first female deejay ever to perform there, and she is also the first female Jamaican deejay to tour internationally. She had further success with singles such as “One Two”, “Money Can’t Buy Me Love”, “Transport Connection” and “Bam Bam”. Her debut album, One Two was released in 1982. She went on to work with producer Henry “Junjo” Lawes, recording “A No Any Man Can Test Sister Nancy”, “Bang Belly”, and a collaboration with Yellowman, “Jah Mek Us Fe A Purpose”. She continued to appear live, sometimes on Jahlove Music with her brother. The sound system toured internationally, with both Sister Nancy and Brigadier Jerry making their debut UK performances at the Brixton Town Hall, London in 1982.